1234835-95-0

Upstream product

• 186552-95-4 1-(3-bromoprop-1-en-2-yl)-4-methoxybenzene 
• 10285-80-0 N-tosyl-3-butenylamine 
• 1234835-62-1 C₁₁H₁₄O₄S 
• 1234835-75-6 N-(but-3-enyl)-N-(2-(4-methoxyphenyl)allyl)-p-toluenesulfonamide 

Downstream Products

• 906360-23-4 3-(4-methoxyphenyl)-1-p-toluenesulfonylpiperidine 

Relevant academic research and scientific papers

Synthesis method of 5-phenyl-1, 2, 3, 6-tetrahydropyridine derivative

The invention discloses a synthesis method of a 5-phenyl-1, 2, 3, 6-tetrahydropyridine derivative. The method includes: in a reaction solvent, taking a non-activated alkyl halogenated hydrocarbon derivative as the reaction raw material, under the action of a metal palladium catalyst, carrying out reaction to obtain a polysubstituted 5-phenyl-1, 2, 3, 6-tetrahydropyridine derivative. The method provided by the invention has the advantages of mild reaction conditions, cheap and easily available original raw materials, mature substrate synthetic route, no special requirement, simple method, and strong operability, provides a key skeleton structure for high efficiency synthesis of multiple drug molecules and natural products, and can be widely applicable to industrial large-scale production.

Chiral hetero- and carbocyclic compounds from the asymmetric hydrogenation of cyclic alkenes

Several types of chiral hetero- and carbocyclic compounds have been synthesized by using the asymmetric hydrogenation of cyclic alkenes. N,P-Ligated iridium catalysts reduced six-membered cyclic alkenes with various substituents and heterofunctionality in good to excellent enantioselectivity, whereas the reduction of five-membered cyclic alkenes was generally less selective, giving modest enantiomeric excesses. The stereoselectivity of the hydrogenation depended more strongly on the substrate structure for the five- rather than the six-membered cyclic alkenes. The major enantiomer formed in the reduction of six-membered alkenes could be predicted from a selectivity model and isomeric alkenes had complementary enantioselectivity, giving opposite optical isomers upon hydrogenation. The utility of the reaction was demonstrated by using it as a key step in the preparation of chiral 1,3-cis-cyclohexane carboxylates. Copyright

Highly flexible synthesis of chiral azacycles via iridium-catalyzed hydrogenation

A range of saturated chiral azacycles has been prepared in high yield and with high selectivity from simple starting materials. A modular approach with ring-closing metathesis as a key step was used to produce a number of five-, six-, and seven-membered c