1234882-95-1Relevant articles and documents
Facile access to chiral ketones through metal-free oxidative C-C bond cleavage of aldehydes by O2
Tiwari, Bhoopendra,Zhang, Junmin,Chi, Yonggui Robin
supporting information; experimental part, p. 1911 - 1914 (2012/04/23)
Giving the metal the boot: The title reaction provides facile access to functionalized chiral ketones from chiral α,α′-disubstituted aldehydes in the presence of molecular oxygen (see scheme). The C-C bond-cleavage approach offers an alternative or better method relative to the typical bond-forming strategies used in synthesizing chiral ketones.