1234890-22-2Relevant academic research and scientific papers
Iridium complex with antiangiogenic properties
Wilbuer, Alexander,Vlecken, Danielle H.,Schmitz, Daan J.,Kraeling, Katja,Harms, Klaus,Bagowski, Christoph P.,Meggers, Eric
, p. 3839 - 3842 (2010/08/19)
(Figure Presented) Identified as nanomolar and selective Inhibitor of receptor protein kinase VEG FR3 (Flt4), the nontoxic and octahedrally coordinated IrIII complex 1 was synthesized by a stereoselective oxidative addition to a square-planar coordinated IrI precursor. The arrows in the image indicate positions at which the blood vessel formation in a zebrafish model of angiogenesis has been hampered by 1.
