1234908-38-3

Basic information

• Product Name: ethyl 2-fluoro-2-([1,1'-biphenyl]-4-yl)acetate
• Synonyms: ethyl 2-fluoro-2-([1,1'-biphenyl]-4-yl)acetate
• CAS NO: 1234908-38-3
• Molecular Weight: 258.292
• Mol File: 1234908-38-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-fluoro-2-([1,1'-biphenyl]-4-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-fluoro-2-([1,1'-biphenyl]-4-yl)acetate(1234908-38-3)
• EPA Substance Registry System: ethyl 2-fluoro-2-([1,1'-biphenyl]-4-yl)acetate(1234908-38-3)

Safety Data

• Hazardous Substances Data: 1234908-38-3(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 5728-52-9 (4-biphenylyl)acetic acid 

Downstream Products

• 5728-52-9 (4-biphenylyl)acetic acid 
• 1379664-89-7 2-([1,1'-biphenyl]-4-yl)-2-fluoroacetic acid 
• 459-72-3 ethyl 2-fluoroacetate 

Relevant articles and documents

Divergent Synthesis of α-Fluorinated Carbonyl and Carboxyl Derivatives by Double Electrophilic Activation of Amides

A straightforward and divergent entry to α-fluorinated carbonyl and carboxyl derivatives is reported. Upon activation of amides with triflic anhydride and a 2-halo-pyridine and subsequent trapping of the resulting keteniminium ions with nucleophiles followed by a second electrophilic activation with NFSI and final hydrolysis, a range of amides can be transformed to α-fluorinated ketones, esters, and amides under mild conditions. Moreover, this reaction can be performed to yield enantioenriched products with a traceless chiral auxiliary.