1235-98-9

Basic information

• Product Name: 17-hydroxypregna-4,20-dien-3-one
• CAS NO: 1235-98-9
• Molecular Formula: C₂₁H₃₀O₂
• Molecular Weight: 314.4617
• Mol File: 1235-98-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 444°C at 760 mmHg
• Flash Point: 189.2°C
• Density: 1.1g/cm³
• Vapor Pressure: 9.48E-10mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 17-hydroxypregna-4,20-dien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 17-hydroxypregna-4,20-dien-3-one(1235-98-9)
• EPA Substance Registry System: 17-hydroxypregna-4,20-dien-3-one(1235-98-9)

Safety Data

• Hazardous Substances Data: 1235-98-9(Hazardous Substances Data)

Usage

Classification

Naturally occurring steroid hormone

Role

Precursor to cortisol and androstenedione

Production sites

Adrenal glands and gonads

Physiological processes involved

Regulation of menstrual cycle
Pregnancy
Development of secondary sexual characteristics

Medical uses

Treatment of congenital adrenal hyperplasia
Support of pregnancy in women at risk of preterm birth

Industrial significance

Important intermediate compound in the synthesis of corticosteroids and sex hormones

Relevance

Significant molecule in endocrinology and steroid chemistry

Upstream product

• 157196-48-0 17β-Hydroxy-17α-(Z-2-tributylstannylvinyl)-4-androsten-3-one 
• 157196-48-0 C₃₃H₅₆O₂Sn 
• 3604-60-2 17alpha-ethynyl-3beta,17beta-dihydroxy-androst-5-ene 
• 434-03-7 ethisterone 
• 434-03-7 levonorgestrel 
• 10291-86-8 17βH-pregna-5,20-diene-3ξ,17-diol 

Relevant articles and documents

Method for catalytically reducing alkynes into olefins through visible light induction

The invention discloses a method for catalytically reducing alkynes into olefins through visible light induction. The method can avoid generation of over-reduced alkane products and the highest yieldis 99%. The method comprises the following steps: by taking an alkyne as a raw material, adding a photosensitizer and a cobalt catalyst, then adding a phosphine ligand or bipyridine ligand, an electronic sacrificial reagent, acetic acid and an organic solvent under inert gas protection, and irradiating with blue light at room temperature for 7-14 hours; and after the reaction is finished, spin-drying an obtained reaction solution, and carrying out silica gel column chromatography separation to obtain an olefin product; wherein the organic solvent is 1, 4-dioxane or tetrahydrofuran, and the alkyne is an aliphatic alkyne or an aromatic alkyne. Reduction of alkyne is realized through a hydrogen transfer strategy, use of dangerous hydrogen is avoided, generation of overreduction products is avoided, reaction conditions are mild, the reaction yield is high, and the method has a good application prospect.

Novel steroidal antiestrogens and antiandrogens and uses thereof

The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive di