1235103-40-8

Basic information

• Product Name: 2-(3,5-dibromo-4-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline
• Synonyms: 2-(3,5-dibromo-4-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline
• CAS NO: 1235103-40-8
• Molecular Weight: 470.123
• Mol File: 1235103-40-8.mol

Chemical Properties

• CAS DataBase Reference: 2-(3,5-dibromo-4-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-dibromo-4-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline(1235103-40-8)
• EPA Substance Registry System: 2-(3,5-dibromo-4-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline(1235103-40-8)

Safety Data

• Hazardous Substances Data: 1235103-40-8(Hazardous Substances Data)

Upstream product

• 27318-90-7 1,10-phenanthroline-5,6-dione 
• 2973-77-5 3,5-dibromo-4-hydroxybenzaldehyde 

Relevant articles and documents

2-(3,5-Dibromo-4-hydroxyphenyl)imidazo [4,5-f][1,10] phenanthrolinoruthenium(II) complexes: Synthesis, characterization, cytotoxicity, apoptosis, DNA-binding and antioxidant activity

A new ligand DBHIP and its two ruthenium(II) complexes [Ru(dmb) 2(DBHIP)](ClO4)2 (1) and [Ru(dmp) 2(DBHIP)](ClO4)2 (2) have been synthesized and characterized. The cytotoxicity of DBHIP and complexes 1 and 2 has been assessed by MTT assay. The apoptosis studies were carried out with acridine orange/ethidium bromide (AO/EB) staining methods. The binding behaviors of these complexes to calf thymus DNA (CT-DNA) were studied by absorption titration, viscosity measurements, thermal denaturation and photoactivated cleavage. The DNA-binding constants of complexes 1 and 2 were determined to be 8.64 ± 0.16 × 10 (s = 1.34) and 2.79 ± 0.21 × 10 (s = 2.17) M -1. The results suggest that these complexes interact with DNA through intercalative mode. The studies on the mechanism of photocleavage demonstrate that superoxide anion radical (O2?-) and singlet oxygen (1O2) may play an important role in the DNA cleavage. The experiments on antioxidant activity show that these compounds also exhibit good antioxidant activity against hydroxyl radical (OH ?). Springer Science+Business Media, LLC. 2010.

Synthesis of ruthenium(II) complexes and characterization of their cytotoxicity in vitro, apoptosis, DNA-binding and antioxidant activity

A new ligand DBHIP and its two ruthenium (II) complexes [Ru(bpy) 2(DBHIP)](ClO4)2 (1) and [Ru (phen) 2(DBHIP)](ClO4)2 (2) have been synthesized and characterized. The binding behaviors of the two complexes to calf thymus DNA were investigated by absorption spectra, viscosity measurements, thermal denaturation and photoactivated cleavage. The DNA-binding constants for complexes 1 and 2 have been determined to be 8.87 ± 0.27 × 10 4M-1 (s= 1.83) and 1.32 ± 0.31 × 10 5 M-1 (s= 1.84). The results suggest that these complexes interact with DNA through intercalative mode. The cytotoxicity of DBHIP, complexes 1 and 2 has been evaluated by MTTassay. The apoptosis assay was carried out with acridine orange/ethidiumbromide (AO/EB) staining methods. The studies on the mechanism of photocleavage demonstrate that superoxide anion radical (O?-2) and singlet oxygen (1O 2) may play an important role.