123511-58-0

Basic information

• Product Name: 2-Benzothiazolecarboxaldehyde,6-methoxy-(9CI)
• Synonyms: 2-Benzothiazolecarboxaldehyde,6-methoxy-(9CI);6-methoxybenzo[d]thiazole-2-carbaldehyde;6-methoxy-2-benzothiazolecarboxaldehyde;6-Methoxybenzothiazole-2-carboxaldehyde;6-methoxy-1,3-benzothiazole-2-carbaldehyde
• CAS NO: 123511-58-0
• Molecular Formula: C₉H₇NO₂S
• Molecular Weight: 193.23
• Product Categories: BENZOTHIAZOLE
• Mol File: 123511-58-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Benzothiazolecarboxaldehyde,6-methoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzothiazolecarboxaldehyde,6-methoxy-(9CI)(123511-58-0)
• EPA Substance Registry System: 2-Benzothiazolecarboxaldehyde,6-methoxy-(9CI)(123511-58-0)

Safety Data

• Hazardous Substances Data: 123511-58-0(Hazardous Substances Data)

Upstream product

• 1451260-80-2 C₁₁H₁₁NO₃S 
• 2942-13-4 6-methoxy-1,3-benzothiazole 
• 68-12-2 N,N-dimethyl-formamide 
• 5310-18-9 N-(4-methoxyphenyl)thioacetamide 
• 104-94-9 4-methoxy-aniline 
• 51-66-1 4-methoxyacetanilide 
• 1747-60-0 6-methoxybenzothiazol-2-ylamine 
• 2941-58-4 2-bromo-6-methoxy-1,3 benzothiazole 
• 2941-72-2 6-methoxy-2-methylbenzothiazole 

Relevant articles and documents

alpha-SYNUCLEIN AGGREGATE BINDING AGENT AND IMAGING METHOD

The present invention provides an α-synuclein aggregate binding agent that has high binding selectivity for an α-synuclein aggregate. The α-synuclein aggregate binding agent contains a compound represented by a formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: in the formula (I), R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; the ring A is a benzene or pyridine ring; the ring B is represented by the following formula (i) or (ii): R4 and R5 are each independently selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl.

Catalytic Deprotonative α-Formylation of Heteroarenes by an Amide Base Generated in Situ from Tetramethylammonium Fluoride and Tris(trimethylsilyl)amine

Heteroarene formylations in DMF solution proceed in the presence of an amide base catalyst generated in situ from tetramethylammonium fluoride (TMAF) and tris(trimethylsilyl)amine (N(TMS)3). The reaction proceeds at room temperature and has an operationally simple procedure. Various heteroarenes, including benzothiophene, thiophene, benzothiazole, oxazole, and indole derivatives, can be formylated with high functional group tolerance.

Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents

Based on our previous results and literature precedence, a series of 2-anilinopyridinyl-benzothiazole Schiff bases were rationally designed by performing molecular modeling experiments on some selected molecules. The binding energies of the docked molecules were better than the E7010, and the Schiff base with trimethoxy group on benzothiazole moiety, 4y was the best. This was followed by the synthesis of a series of the designed molecules by a convenient synthetic route and evaluation of their anticancer potential. Most of the compounds have shown significant growth inhibition against the tested cell lines and the compound 4y exhibited good antiproliferative activity with a GI50 value of 3.8?μM specifically against the cell line DU145. In agreement with the docking results, 4y exerted cytotoxicity by the disruption of the microtubule dynamics by inhibiting tubulin polymerization via effective binding into colchicine domain, comparable to E7010. Detailed binding modes of 4y with colchicine binding site of tubulin were studied by molecular docking. Furthermore, 4y induced apoptosis as evidenced by biological studies like mitochondrial membrane potential, caspase-3, and Annexin V-FITC assays.