123522-80-5

Upstream product

• 123522-79-2 tert-Butyl-((R)-6-methyl-1,4-dioxa-spiro[4.5]dec-6-ylmethoxy)-diphenyl-silane 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 252979-21-8 (R)-2-(hydroxymethyl)-2-methylcyclohexanone 
• 123522-78-1 (R)-6-Methyl-1,4-dioxa-spiro[4.5]decane-6-carbaldehyde 
• 123522-69-0 ((R)-6-Methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-methanol 
• 123522-75-8 methyl (R)-3-(6-methyl-1,4-dioxaspiro[4.5]decan-6-yl)propanoate 
• 53068-89-6 (R)-(+)-2-(2'-carbomethoxyethyl)-2-methylcyclohexanone 
• 252979-18-3 (R)-6-acetoxymethyl-3-(methoxymethoxy)-6-methyl-2-cyclohexenone 
• 147728-67-4 6-methyl-3-methoxymethyloxy-2-cyclohexenone 
• 111596-58-8 3-(methoxymethoxy)-2-cyclohexenone 
• 123522-76-9 3-((R)-6-Methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-2-phenylselanyl-propionic acid methyl ester 
• 123522-68-9 methyl (1'R)-3-<2'-(ethylenedioxy)-1'-methylcyclohexyl>prop-2-enoate 
• 252979-14-9 (+/-)-6-hydroxymethyl-3-(methoxymethoxy)-6-methyl-2-cyclohexenone 

Downstream Products

• 123522-74-7 (S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,4-dimethyl-cyclohex-2-enone 
• 123522-73-6 (R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol 
• 123522-71-4 (6R)-4-(tert-butyldiphenylsilyloxymethyl)-2,6-dimethyl-2-cyclohexenone 
• 117479-71-7 (+)-Cassiol 
• 123522-70-3 (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2,6-dimethyl-cyclohexanone 

Relevant academic research and scientific papers

Synthesis of optically active 3-alkoxy-6-hydroxymethyl-6-methyl-2-cyclohexenone

Optically active 3-alkoxy-6-hydroxymethyl-6-methyl-2-cyclohexenone and 6-acetoxymethyl-3-alkoxy-6-methyl-2-cyclohexenone were efficiently obtained by lipase-catalyzed kinetic resolution. (R)-6-Acetoxymethyl-3-(methoxymethoxy)-6-methyl-2-cyclohexenone was converted to the synthetic intermediate of cassiol.

FIRST TOTAL SYNTHESIS OF (+)-CASSIOL. A POTENT ANTIULCEROGENIC COMPOUND

The first total synthesis of (S)-(+)-Cassiol (2) is described.