1235258-94-2Relevant academic research and scientific papers
Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins
Simoni, Daniele,Lee, Ray M.,Durrant, David E.,Chi, Nai-Wen,Baruchello, Riccardo,Rondanin, Riccardo,Rullo, Cinzia,Marchetti, Paolo
scheme or table, p. 3431 - 3435 (2010/08/06)
A representative series of structural analogues of the antimitotic tripeptides hemiasterlins have been synthesized. The key-step of this synthetic strategy consists of an Ag2O-promoted nucleophilic substitution on a common precursor, a chiral non-racemic 2-bromoacyl derivative. Simple variation of nucleophile substituents allows a rapid and stereocontrolled development of new series of derivatives. Some reported compounds showed potent biological activity as growth inhibitors of cancer cell lines and tubulin polymerization inhibitors.
