1235306-53-2Relevant academic research and scientific papers
A versatile catalyst for intermolecular direct arylation of Indoles with benzoic acids as arylating reagents
Zhou, Jun,Hu, Peng,Zhang, Min,Huang, Shijun,Wang, Min,Su, Weiping
supporting information; experimental part, p. 5876 - 5881 (2010/09/05)
(Figure Presented) Coupled together: With a versatile catalyst system (Pd(TFA)2/Ag2CO3/propionic acid) both electron-rich and -deficient benzoic acids serve as arylating reagents for the direct functionalization of a wide rage of indoles by a combination of decarboxylation and C-H bond activation. Depending on the nature of the benzoic acids, the reaction occurs selectively at either the C2- or C3-position of indoles, which may arise from two different catalytic pathways (see scheme; TFA = trifluoroacetate).
