123531-54-4

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-imidazo[1,2-b]pyridazine-3-carbonitrile is utilized as an intermediate compound in the synthesis of various pharmaceuticals. Its unique structure and functional groups make it a valuable building block for the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Research:
In the field of chemical research, 6-Chloro-imidazo[1,2-b]pyridazine-3-carbonitrile serves as a subject for study, allowing scientists to explore its chemical behavior, reactivity, and potential applications in the synthesis of other complex molecules. 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-CARBONITRILE's properties can provide insights into the broader class of heterocyclic compounds and their potential uses.
Used in Material Science:
6-Chloro-imidazo[1,2-b]pyridazine-3-carbonitrile may also find applications in material science, particularly in the development of new materials with unique electronic, optical, or mechanical properties. 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-CARBONITRILE's structure and functional groups could contribute to the creation of novel materials with potential uses in various industries, such as electronics or aerospace.

Upstream product

• 590-17-0 cyanomethyl bromide 
• 35053-54-4 N,N-dimethyl-N'-pyridazin-3-yl-formamidine 
• 106-96-7 propargyl bromide 
• 35053-55-5 N'-(6-chloropyridazin-3-yl)-N,N-dimethylmethanimidamide 

Relevant academic research and scientific papers

Synthesis method of 6-chloroimidazo[1, 2-b]pyridazine-3-carbonitrile

The invention relates to a synthesis method of 6-chloroimidazo[1, 2b]pyridazine-3-carbonitrile, which comprises the following steps of 1, adding N, N-dimethylformamide dimethyl acetal into a reactor to react with 3-amino-6-chloropyridazine, thereby obtaining an N, N-dimethyl-N'-3-(6-chloro-pyridazine)yl-formamidine intermediate; 2, adding a solvent into the N, N-dimethyl-N'-3-(6-chloro-pyridazine)yl-formamidine intermediate obtained in the step 1, mixing, adding bromoacetonitrile, reacting, adding alkali liquor, standing, separating out solid, and filtering to obtain a solid mixture, 3, completely dissolving the solid mixture obtained in the step 4 in ethyl acetate, washing with water and saturated edible salt water, drying, filtering, and removing ethyl acetate to obtain a crude product of 6-chloroimidazo[1, 2-b]pyridazine-3-carbonitrile, and 4, recrystallizing the crude product of the 6-chloroimidazo[1, 2-b]pyridazine-3-carbonitrile, and filtering to obtain a pure product of the 6-chloroimidazo[1, 2-b] pyridazine-3-carbonitrile. The method is short in overall process time, and the obtained product is stable in quality and high in purity.

Convenient two-step one-pot synthesis of 3-substituted imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines

Abstract: A convenient and novel two-step one-pot method for the synthesis of 3-substituted imidazo[1,2-a]pyridines and 3-substituted imidazo[1,2-b]pyridazines was developed through the reaction of heterocyclic amines and N,?N-dimethylformamide dimethyl a

TGF-Beta Inhibitors

Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R1 and R′ are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-β, and can be used to treat disease by blocking TGF-β signaling.

COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.

IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS

There is provided compounds of formula (I): wherein Z, M, R1, X, R3, R4 and R5 have meanings given in the description, an pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protei kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, an particularly in the treatment of cancer.