123533-08-4Relevant academic research and scientific papers
Synthesis and evaluation of new 2',3'-dideoxynucleoside analogs as potential anti-AIDS and anti-herpes drugs
Faraj,Maillard,Lemaitre,Letellier,Frappier,Florent,Grierson,Monneret,Zerial
, p. 141 - 148 (2007/10/02)
Based on the known structure-activity relationships for the active anti-HIV, a series of 3'-deoxy-3'-N-functionalized thymidine analogs has been synthesized from thymidine. Evaluation for inhibitory activity against human immunodeficiency virus (HIV) replication in CEM cells and against herpes simplex virus in MRC-5 cells is reported.
SYNTHESIS OF 3'SUBSTITUTED-2',3'-DIDEOXYNUCLEOSIDE ANALOGS AS POTENTIAL ANTI-AIDS DRUGS
Maillard, Michel,Faraj, Abdesslem,Frappier, Francois,Florent, Jean-Claude,Grierson, David S.,Monneret, Claude
, p. 1955 - 1958 (2007/10/02)
3'-Amino-3'-deoxythymidine 9 was prepared in six steps and in 67percent overall yield from thymidine.Five derivatives of 9 and compound 17 were tested for their anti-HIV activity.
