1235366-64-9

Upstream product

• 1235367-24-4 C₁₁H₁₃ClO₅ 
• 625-31-0 (S)-4-penten-2-ol 

Downstream Products

• 853645-37-1 (R)-(-)-3-chloro-4,6-bis-ethoxymethoxy-2-methylbenzoic acid 1-methylbut-3-enyl ester 

Relevant academic research and scientific papers

MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90

Disclosed are macrocyclic compounds of formulae I-V,which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90.