1235453-07-2Relevant academic research and scientific papers
Determination of the structure and its absolute configuration of 2″-hydroxynicotianamine, an inhibitor against Angiotensin-I converting enzyme in buckwheat, through the total synthesis
Yoshikawa, Keisuke,Watanabe, Hidenori,Aoyagi, Yasuo,Kitahara, Takeshi
experimental part, p. 1435 - 1444 (2011/01/12)
Nicotianamine is known as an inhibitor against Angiotensin-I Converting Enzyme (ACE). We synthesized a new nicotianamine derivative with an additional hydroxy group isolated from buckwheat (Fagopyrum esculentum Moench) powder and determined its regio and stereochemistry unambiguously by the enantioselective synthesis of diastereomers.
Efficient synthesis of nicotianamine and non-natural analogues
Bouazaoui, M'Barek,Larrouy, Manuel,Martinez, Jean,Cavelier, Florine
experimental part, p. 6609 - 6617 (2011/02/25)
An efficient synthesis of nicotianamine has been achieved by using a new strategy based on N-alkylation. Sulfonamide activation proved to be necessary for the alkylation of the primary amine and the 2-(trimethylsilyl)ethanesulfonyl group was easily introd
