1235461-14-9

Basic information

• Product Name: 6-(3,4-dichlorophenyl)-3-(4-morpholinylcarbonyl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide
• CAS NO: 1235461-14-9
• Molecular Weight: 472.371
• Mol File: 1235461-14-9.mol

Chemical Properties

• CAS DataBase Reference: 6-(3,4-dichlorophenyl)-3-(4-morpholinylcarbonyl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3,4-dichlorophenyl)-3-(4-morpholinylcarbonyl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide(1235461-14-9)
• EPA Substance Registry System: 6-(3,4-dichlorophenyl)-3-(4-morpholinylcarbonyl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide(1235461-14-9)

Safety Data

• Hazardous Substances Data: 1235461-14-9(Hazardous Substances Data)

Upstream product

• 177192-82-4 C₇H₇BrN₂O₂ 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 1235466-99-5 6-bromo-3-(morpholine-4-carbonyl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide 
• 151169-75-4 3,4-dichlophenylboronic acid 
• 1235466-98-4 6-bromo-8-carbamoyl-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid 

Relevant articles and documents

9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors

The discovery, synthesis, and characterization of 9H-carbazole-1-carboxamides as potent and selective ATP-competitive inhibitors of Janus kinase 2 (JAK2) are discussed. Optimization for JAK family selectivity led to compounds 14 and 21, with greater than 45-fold selectivity for JAK2 over all other members of the JAK kinase family.

CARBAZOLE AND CARBOLINE KINASE INHIBITORS

The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) compounds inhibit tyrosine kinase activity of Jak2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.