1235472-02-2

Upstream product

• 1235473-95-6 methyl 6-bromo-3-hydroxy-1-oxo-4-phenyl-2-({1-[(3-phenyl-5-isoxazolyl)methyl]-4-piperidinyl}methyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate 

Downstream Products

• 1235472-03-3 methyl 1-oxo-4-phenyl-2-({1-[(3-phenyl-5-isoxazolyl)methyl]-4-piperidinyl}methyl)-1,2-dihydro-3-isoquinolinecarboxylate 
• 1235472-04-4 methyl 6-chloro-1-oxo-4-phenyl-2-({1-[(3-phenyl-5-isoxazolyl)methyl]-4-piperidinyl}methyl)-1,2-dihydro-3-isoquinolinecarboxylate 

Relevant academic research and scientific papers

PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF

A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.