1235477-15-2Relevant academic research and scientific papers
Synthesis of uracil derivatives and their alkylation: An approach to peptide non-nucleic acid monomers
Jachak, Madhukar N.,Birari, Dilip R.,Toche, Raghunath B.,Ghagare, Maruti G.,Bagul, Sandeep M.
experimental part, p. 451 - 459 (2011/07/29)
N3-substituted 5-acetyluracils derived from corresponding N 3-substituted 5-acetylcytosines are versatile functional precursors that allow the introduction of various aliphatic, aromatic, carbocyclic, and carbamoyl functionalities at N1-position. A series of 1,3-disubstituted 5-acetyluracils were synthesized by alkylation at N 1-position. For the introduction of carbamoyl functionalities a convergent approach is studied, leading to N-arylacetamide derivatives; the linear approach furnished peptide non-nucleic acid monomers by replacement of active ester with amino acid esters in good yields.
