123548-16-3 Usage
Uses
AQ-RA 741 acts as a potent and highly specific muscarinic M2 receptor antagonist, with potential application towards the development of bronchodilator anti-muscarinic agents for humans.
Biological Activity
High affinity, selective muscarinic M 2 receptor antagonist (pK i values are 8.3, 7.7 and 6.82 for M 2 , M 1 and M 3 receptors, respectively). In vivo, displays cardioselectivity over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.
references
[1]. doods h, entzeroth m and mayer n. cardioselectivity of aq-ra 741, a novel tricyclic antimuscarinic drug. eur j pharmacol, 1991, 192(1):147-52.[2]. gomeza j, shannon h, kostenis e, et al. pronounced pharmacologic deficits in m2 muscarinic acetylcholine receptor knockout mice. proc natl acad sci u s a, 1999, 96(4):1692-7.
Check Digit Verification of cas no
The CAS Registry Mumber 123548-16-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,5,4 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 123548-16:
(8*1)+(7*2)+(6*3)+(5*5)+(4*4)+(3*8)+(2*1)+(1*6)=113
113 % 10 = 3
So 123548-16-3 is a valid CAS Registry Number.
InChI:InChI=1/C27H37N5O2/c1-3-30(4-2)17-8-7-10-21-14-18-31(19-15-21)20-25(33)32-24-13-6-5-11-22(24)27(34)29-23-12-9-16-28-26(23)32/h5-6,9,11-13,16,21H,3-4,7-8,10,14-15,17-20H2,1-2H3,(H,29,34)