1235487-00-9Relevant academic research and scientific papers
Discovery of RG7112: A small-molecule MDM2 inhibitor in clinical development
Vu, Binh,Wovkulich, Peter,Pizzolato, Giacomo,Lovey, Allen,Ding, Qingjie,Jiang, Nan,Liu, Jin-Jun,Zhao, Chunlin,Glenn, Kelli,Wen, Yang,Tovar, Christian,Packman, Kathryn,Vassilev, Lyubomir,Graves, Bradford
, p. 466 - 469 (2013)
The p53 tumor suppressor is a potent transcription factor that plays a key role in the regulation of cellular responses to stress. It is controlled by its negative regulator MDM2, which binds directly to p53 and inhibits its transcriptional activity. MDM2
