1235489-75-4Relevant academic research and scientific papers
Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors
Shih, Hao-Wei,Chen, Kuo-Ting,Chen, Shao-Kang,Huang, Chia-Ying,Cheng, Ting-Jen R,Ma, Che,Wong, Chi-Huey,Cheng, Wei-Chieh
supporting information; experimental part, p. 2586 - 2593 (2010/08/07)
The development of iminocyclitol-based small molecule libraries against a bacterial TGase is described. An iminocyclitol was conjugated with a pyrophosphate mimic using either a 1,3-dipolar cycloaddition or reductive amination reaction, which was then condensed with a variety of lipophilic carboxylic acids in an amide bond coupling to generate a desired molecular library. With assistance of microtiter plate-based combinatorial chemistry and in situ screening, a potential inhibitor, the first potent iminocyclitol-based inhibitor against bacterial TGases was efficiently developed. The Royal Society of Chemistry 2010.
