1235550-95-4Relevant academic research and scientific papers
Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: Pilicides with increased antivirulence activity
Chorell, Erik,Pinkner, Jerome S.,Phan, Gilles,Edvinsson, Sofie,Buelens, Floris,Remaut, Han,Waksman, Gabriel,Hultgren, Scott J.,Almqvist, Fredrik
supporting information; experimental part, p. 5690 - 5695 (2010/10/20)
Pilicides block pili formation by binding to pilus chaperones and blocking their function in the chaperone/usher pathway in E. coli. Various C-2 substituents were introduced on the pilicide scaffold by design and synthetic method developments. Experimenta
