123574-90-3

Upstream product

• 134-81-6 benzil 
• 1571-08-0 methyl 4-formylbenzoate 

Downstream Products

• 1234575-81-5 methyl 4-(1-n-butyl-4,5-diphenylimidazol-2-yl)benzoate 

Relevant academic research and scientific papers

Facile fabrication of porous magnetic covalent organic frameworks as robust platform for multicomponent reaction

The design of cheap yet efficient nanoporous magnetic catalysts for the environmentally benign process's widespread application is an extremely attractive, challenging chemical research field. A novel porous magnetic covalent organic framework was prepared by the condensation reaction of melamine and terephthaladehyde on the surface of 3,4-dihydroxybenzaldehyde coated magnetic Fe3O4 nanoparticles COF@Fe3O4 under hydrothermal conditions for the first time. The high surface area magnetic COF could exhibit superior catalytic activity for sustainable synthesis of trisubstituted and tetrasubstituted imidazoles and pyrroles in good to excellent yields in PEG as solvent under environmentally friendly, ambient conditions and making the overall process economical, efficient, and green. The retrievable catalyst in PEG is general and applicable to a broad substrate scope and functional group compatibility. The structure and morphology of the COF@Fe3O4 were characterized by FTIR, XRD, EDX, and SEM spectroscopy. The COF@Fe3O4 magnetic catalyst was recovered by an external magnet and used for several cycles without significant catalytic activity loss.

An expedient one-pot synthesis of highly substituted imidazoles using supported ionic liquid-like phase (SILLP) as a green and efficient catalyst and evaluation of their anti-microbial activity

An efficient method for the synthesis of imidazole derivatives by a three-component condensation of benzil or 9,10-phenanthrenequinone, aldehydes and ammonium acetate using supported ionic liquid-like phase (SILLP) catalyst under ultrasonic irradiation or classical heating conditions is reported. The present methodology offers several advantages, such as excellent yields, simple procedures, short reaction times, simple work-up and mild conditions. The catalyst is easily separated from the products by filtration and also exhibits remarkable reusable activity. These highly substituted imidazoles were also evaluated for their anti-microbial activity.

Potassium aluminum sulfate (alum): An efficient catalyst for the one-pot synthesis of trisubstituted imidazoles

Trisubstituted imidazoles were synthesized in high yields in the presence of potassium aluminum sulfate (alum) as a non-toxic, reusable, inexpensive, and easily available reagent at 70°C.

Synthesis and biological evaluation of novel 2,4,5-triarylimidazole–1,2,3-triazole derivatives via click chemistry as α-glucosidase inhibitors

A novel series of 2,4,5-triarylimidazole–1,2,3-triazole derivatives were synthesized via copper(I)-catalyzed azide–alkyne click chemistry, and evaluated for their α-glucosidase inhibitory activity. All tested compounds showed potent α-glucosidase inhibitory activity with IC50ranging from 15.16 ± 0.18 to 48.15 ± 0.37 μM, in comparison to the standard drug, acarbose (IC50= 817.38 ± 6.27 μM). Among all the tested compounds, 5j was found to be the most active compound with IC50value of 15.16 ± 0.18 μM and behaved as a noncompetitive inhibitor with a Kiof 14.78 μM. In addition, molecular docking study was carried out to explore the binding interactions of these compounds with α-glucosidase enzyme.

Fluorescent molecular probe for detecting picric acid and preparation method and application thereof

The invention provides a fluorescent molecular probe for detecting picric acid and a preparation method and application thereof, and belongs to the technical field of fluorescent probes. The fluorescent molecular probe is prepared from 1, 2-diphenyl ethanedione, methyl p-formylbenzoate and ammonium acetate through a one-step reaction; and the preparation method is simple, the raw materials are low in price, and the product is easy to purify. The molecular probe has good selectivity and high sensitivity to picric acid, the detection process is simple and rapid, and visual qualitative detection can be carried out on picric acid; the picric acid can be quantitatively detected by using a good linear relationship between the fluorescence emission intensity and the picric acid concentration; and therefore, the probe molecule has a potential application prospect in the aspect of picric acid detection and recognition.

Simple and efficient method for the synthesis of highly substituted imidazoles catalyzed by benzotriazole

Benzotriazole is an efficient, readily available, and simple catalyst for the synthesis of 2,4,5-trisubstituted imidazoles in high yields from 1,2-diketones and aldehydes in the presence of NH4OAc via multi-components reaction. The significant features of this one-pot procedure are very simple operation, easy work-up and purification of products.

Highly efficient one-pot synthesis of trisubstituted imidazoles under catalyst-free conditions

Operationally simple, atom economical, and scalable synthesis of 2,4,5-trisubstituted imidazoles from benzil, aldehydes, and ammonium acetate is shown to proceed readily in methanol with high yield. The scope of the reaction is quite broad; a variety of aromatic and aliphatic activated and unactivated aldehydes have all been shown to be viable substrates for this reaction. Excellent yields and purity were obtained by washing the products with hot ethanol.

The synthesis and optical properties of novel 1,3,4-oxadiazole derivatives containing an imidazole unit

A series of 1,3,4-oxadiazole derivatives containing an imidazole unit were synthesized and characterized using 1H NMR, 13C NMR, mass spectrometry (or high-resolution mass spectrometry) and elemental analysis. The crystal structure of 2,5-bis(4-(1-n-butyl-4,5-diphenylimidazol-2-yl)phenyl)-1,3,4-oxadiazole was determined as monoclinic, space group C2/c type, using single crystal X-ray crystallography. For nine samples, UV-visible absorption coefficient (e{open}), maximum wavelength (λmax), fluorescence excitation wavelength (λex), fluorescence emission wavelength (λem), fluorescence quantum yield (ΦF), fluorescence lifetime (T) were measured in dichloromethane and in the solid state. For these selected compounds, thermogravimetric analysis was also employed and structure:optical behaviour characteristics were discussed.