123580-44-9

Upstream product

• 64-17-5 ethanol 
• 123580-43-8 3'-O-(carboxymethyl)diosmetin 

Downstream Products

• 930774-56-4 4-{[2-(3-ethoxycarbonylmethoxy-4-methoxy-phenyl)-5-hydroxy-4-oxo-4H-chromen-7-yloxy]-acetyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 123580-49-4 5-hydroxy-7,3'-bis(2-ethoxy-2-oxoethoxy)-4'-methoxyflavone 
• 123580-46-1 7-[2-{4-[(2,3,4-Trimethoxyphenyl)methyl]-1-piperazinyl}-2-oxoethoxy]-5-hydroxy-4'-methoxy-3'-(2-ethoxy-2-oxoethoxy)flavone 

Relevant academic research and scientific papers

Flavonoid-related modulators of multidrug resistance: Synthesis, pharmacological activity, and structure-activity relationships

A series of 28 flavonoid derivatives containing a N-benzylpiperazine chain have been synthesized and tested for their ability to modulate multidrug resistance (MDR) in vitro. At 5 μM, most compounds potentiated doxorubicin cytotoxicity on resistant K562/DOX cells. They were also able to increase the intracellular accumulation of JC-1, a fluorescent molecule recently described as a probe of P-glycoprotein-mediated MDR. This suggests that these compounds act, at least in part, by inhibiting P-glycoprotein activity. As in other studies, lipophilicity was shown to influence MDR- modulating activity but was not the only determinant. Diverse di- and trimethoxy substitutions on N-benzyl were examined and found to affect the activity differently. The most active compounds had a 2,3,4- trimethoxybenzylpiperazine chain attached to either a flavone or a flavanone moiety (13, 19, 33, and 37) and were found to be more potent than verapamil.

2-(piperazinyl)-2-oxoethylene-substituted flavonoid compounds

Compound of general formula I: STR1 in which: A is a single or double bond, R1 and R3, which may be identical or different, are each a hydrogen atom, an alkoxycarbonylmethylene radical of formula --CH2 CO2 Rsub