1235809-46-7Relevant academic research and scientific papers
Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 3, aryl substituted pyrrolidines
Bosanac, Todd,Hickey, Eugene R.,Ginn, John,Kashem, Mohammed,Kerr, Steven,Kugler, Stanley,Li, Xiang,Olague, Alan,Schlyer, Sabine,Young, Erick R.R.
, p. 3746 - 3749 (2010)
The discovery and SAR of a series of β-aryl substituted pyrrolidine 2H-isoquinolin-1-one inhibitors of Rho-kinase (ROCK) derived from 2 is herein described. SAR studies have shown that aryl groups in the β-position are optimal for potency. Our efforts foc
