1235835-68-3Relevant academic research and scientific papers
Proline sulphonamide-catalysed Yamada-Otani condensation: Reaction development, substrate scope and scaffold reactivity
Yang, Hua,Banerjee, Somdev,Carter, Rich G.
supporting information; experimental part, p. 4851 - 4863 (2012/08/08)
The development of a proline sulphonamide-catalysed method for enantioselective and diastereoselective construction of functionalized cyclohexenones is described. Impact of catalyst structure as well as solvent effects and additives are explored. A significant substrate scope is demonstrated by variation of both the aldehyde and the enone components. Diastereoselective derivatization of the cyclohexenone scaffold illustrates its utility as a building block for chemical synthesis.
Synthesis of all-carbon, quaternary center-containing cyclohexenones through an organocatalyzed, multicomponent coupling
Yang, Hua,Carter, Rich G.
supporting information; experimental part, p. 3108 - 3111 (2010/09/11)
Organocatalyzed multicomponent coupling using a new ester-containing, proline aryl sulfonamide has been developed for accessing densely functionalized cyclohexenones, each containing a quaternary center in high enantio- and diastereoselectivity. In contrast to most enamine/iminium-catalyzed reactions, the use of molecular sieves was critical to optimum enantioselectivity.
