1235842-48-4

Basic information

• Product Name: 4-Piperidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-4-fluoro-, ethyl ester
• Synonyms: 4-Piperidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-4-fluoro-, ethyl ester;tert-butyl 4-((ethoxycarbonyl)Methyl)-4-fluoropiperidine-1-carboxylate;tert-butyl 4-(2-ethoxy-2-oxoethyl)-4-fluoropiperidine-1-carboxylate
• CAS NO: 1235842-48-4
• Molecular Formula: C14H24FNO4
• Molecular Weight: 289.3430632
• Mol File: 1235842-48-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Piperidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-4-fluoro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-4-fluoro-, ethyl ester(1235842-48-4)
• EPA Substance Registry System: 4-Piperidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-4-fluoro-, ethyl ester(1235842-48-4)

Safety Data

• Hazardous Substances Data: 1235842-48-4(Hazardous Substances Data)

Upstream product

• 401811-97-0 4-ethoxycarbonylmethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 198892-80-7 t-butyl 4-(2-hydroxyethylidene)tetrahydropyridine-1(2H)-carboxylate 
• 1235842-50-8 tert-butyl 4-fluoro-4-(2-hydroxyethyl)piperidine-1-carboxylate 

Relevant articles and documents

TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of tan protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tan protein, such that tan protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tan. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tan protein. Diseases or disorders that result from aggregation or accumulation of tan protein are treated or prevented with compounds and compositions of the present disclosure.

6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES

The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament f