1235863-03-2

Basic information

• Product Name: dibenzyl(2-n-ethyl-9-methyl-9H-purin-6-yl)amin
• Synonyms: dibenzyl(2-n-ethyl-9-methyl-9H-purin-6-yl)amin
• CAS NO: 1235863-03-2
• Molecular Weight: 357.458
• Mol File: 1235863-03-2.mol

Chemical Properties

• CAS DataBase Reference: dibenzyl(2-n-ethyl-9-methyl-9H-purin-6-yl)amin(CAS DataBase Reference)
• NIST Chemistry Reference: dibenzyl(2-n-ethyl-9-methyl-9H-purin-6-yl)amin(1235863-03-2)
• EPA Substance Registry System: dibenzyl(2-n-ethyl-9-methyl-9H-purin-6-yl)amin(1235863-03-2)

Safety Data

• Hazardous Substances Data: 1235863-03-2(Hazardous Substances Data)

Upstream product

• 496955-48-7 dibenzyl-(2-chloro-9-methyl-9H-purin-6-yl)amine 
• 97-94-9 triethyl borane 
• 2386-64-3 ethylmagnesium chloride 

Relevant articles and documents

Development of a practical and sustainable strategy for the synthesis of ST1535 by an iron-catalyzed Kumada cross-coupling reaction

A simple, convenient, and environmentally friendly route to ST1535 employing an iron-catalyzed cross-coupling reaction and butylmagnesium chloride is described.

Direct B-alkyl suzuki-miyaura cross-coupling of 2-halopurines. Practical synthesis of ST1535, a potent adenosine A2A receptor antagonist

(Figure presented) The scope and limitations of using palladium-catalyzed cross-coupling reactions of diverse butyl metal species with two different 2-halopurines were evaluated. While tributylboranes reacted readily and regioselectively with both 2-chloro-6-dibenzylaminopurines and 2-iodo-6-chloropurines, all the other alkyl metal species were much less reactive and gave very poor yield and/or selectivity of the desired product. This protocol was applied to the synthesis of an important adenosine A 2A receptor antagonist, ST1535.