123594-01-4 Usage
General Description
8-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE is a chemical compound with a fluorine atom attached to a tetrahydro-isoquinoline ring structure. It is a heterocyclic compound that has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals and drug research. The compound may be used as a building block for the synthesis of various biologically active molecules and drug candidates. Its unique structure and fluorine substitution make it an interesting target for chemical modification and exploration of its potential biological activities. Overall, 8-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE is an important intermediate in organic synthesis and drug discovery with potential pharmacological and therapeutic significance.
Check Digit Verification of cas no
The CAS Registry Mumber 123594-01-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,5,9 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 123594-01:
(8*1)+(7*2)+(6*3)+(5*5)+(4*9)+(3*4)+(2*0)+(1*1)=114
114 % 10 = 4
So 123594-01-4 is a valid CAS Registry Number.
123594-01-4Relevant articles and documents
Synthesis of 8-fluoro-3,4-dihydroisoquinoline and its transformation to 1,8-disubstituted tetrahydroisoquinolines
Hargitai, Csilla,Nagy, Tamás,Halász, Judit,Simig, Gyula,Volk, Balázs
, (2018)
A simple procedure for the synthesis of 8-fluoro-3,4-dihydroisoquinoline is described below, based on a directed ortho-lithiation reaction. This key intermediate was then applied in various transformations. Fluorine–amine exchange afforded the corresponding 8-amino-3,4-dihydroisoquinolines, suitable starting compounds for the synthesis of 1-substituted 8-amino-tetrahydroisoquinolines. On the other hand, reduction and alkylation reactions of 8-fluoro-3,4-dihydroisoquinoline led to novel 1,2,3,4-tetrahydroisoquinoline derivatives that can be used as building blocks in the synthesis of potential central nervous system drug candidates.
