1235967-69-7Relevant academic research and scientific papers
Synthesis of stable functional titanocene enolates
Gansaeuer, Andreas,Okkel, Andreas,Worgull, Dennis,Schnakenburg, Gregor
, p. 3227 - 3230 (2010)
A modular approach to bench-stable titanocene enolates is described. The reaction of titanocenes containing pendent acid chlorides with activated methylene compounds in the presence of excess base results in the formation of the pivotal enolates. In all cases, the enolates are coordinated to the titanocene, which acts as a stabilizing template in an intramolecular manner, as demonstrated by NMR spectroscopy and X-ray crystallography. Upon protonation with strong acids, the C-C bond formed during the acylation is cleaved. Hence, the template effect can be reversed by adjusting the acidity of the reaction medium.
