1235968-75-8Relevant academic research and scientific papers
Iron-catalyzed cross-coupling between 1-bromoalkynes and grignard-derived organocuprate reagents
Castagnolo, Daniele,Botta, Maurizio
supporting information; experimental part, p. 3224 - 3228 (2010/08/20)
An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes.
