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123597-59-1

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123597-59-1 Usage

General Description

Phorbol 13-Decanoate is a chemical compound that is composed of more than 99% of the phorbol 13-decanoate molecule. It is a member of the phorbol ester family, which is derived from the croton oil of the plant Croton tiglium. Phorbol 13-decanoate is primarily used as a tumor promoter in biological research, where it is employed to induce cell differentiation and proliferation. It is also believed to have potential pharmaceutical applications, although its precise mechanisms of action and potential therapeutic uses are still being studied. Additionally, phorbol 13-decanoate is known for its potential toxic and irritant properties and precautions should be taken when handling it.

Check Digit Verification of cas no

The CAS Registry Mumber 123597-59-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,5,9 and 7 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 123597-59:
(8*1)+(7*2)+(6*3)+(5*5)+(4*9)+(3*7)+(2*5)+(1*9)=141
141 % 10 = 1
So 123597-59-1 is a valid CAS Registry Number.

123597-59-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Phorbol 13-Decanoate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123597-59-1 SDS

123597-59-1Upstream product

123597-59-1Downstream Products

123597-59-1Relevant articles and documents

Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation

Marquez, Nieves,Calzado, Marco A.,Sanchez-Duffhues, Gonzalo,Perez, Moises,Minassi, Alberto,Pagani, Alberto,Appendino, Giovanni,Diaz, Laura,Munoz-Fernandez, Maria Angeles,Munoz, Eduardo

, p. 1370 - 1380 (2008)

The persistence of latent reservoirs of HIV-1 represents a major barrier to virus eradication in patients treated with antiretrovirals. Prostratin is a non-tumor promoting 12-deoxyphorbol monoester capable of up-regulating viral expression from latent provirus and therefore is potentially useful for HIV adjuvant therapy and similar properties might be elicited by related non-tumor promoting phorboids. We have therefore investigated a series of phorbol 13-monoesters for their capacity to reactivate HIV latency. Using a Jurkat T cell line containing latent HIV proviruses, we found that prostratin and phorbol-13-stearate effectively activate HIV-1 gene expression in these latently infected cells, with phorbol-13-stearate being at least 10-fold more potent than prostratin, and its activity rapidly decreasing with a shortening of the acyl side chain. We further demonstrated that phorbol-13-stearate and prostratin stimulate IKK-dependent phosphorylation and degradation of IκBα, leading to activation of NF-κB. Moreover, prostratin, phorbol-13-hexanoate and phorbol-13-stearate also activate the JNK and ERK pathways. Studies with isoform-specific PKC inhibitors suggest that the classical PKCs play a prominent role in the responses elicited by phorbol-13-stearate. Nevertheless, this compound induces a translocation pattern of the PKC isotypes α and δ to cellular compartments distinctly different from that elicited by prostratin and PMA.

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