1235976-50-7Relevant academic research and scientific papers
Synthesis of β-aminovinylphosphonates by organocatalytic nucleophilic displacement of acetate with amines
Garzon, Cécile,Attolini, Mireille,Maffei, Michel
, p. 3772 - 3774 (2010)
The synthesis of diethyl β-aminovinylphosphonates 2 from acetoxy phosphonate 1 is described. The reaction entails an organocatalyzed substitution of the acetoxy group by primary or secondary amines. The use of a catalytic amount of DABCO is necessary if the amine is not nucleophilic enough, otherwise a strong nucleophilic amine can react without organocatalyst. The reaction led to a series of functionalized title compounds in good to excellent yields.
