1235981-99-3Relevant academic research and scientific papers
Total synthesis of (+)-crocacin C
Sirasani, Gopal,Paul, Tapas,Andrade, Rodrigo B.
experimental part, p. 3648 - 3655 (2010/08/03)
Two approaches toward the total synthesis of cytotoxic polyketide natural product (+)-crocacin C (1) are described. The first approach, which was ultimately unsuccessful, was replaced altogether with a second that afforded target 1 in 10 linear steps from commercially available Evans' chiral propionimide (5% overall yield). No protecting groups were utilized in the total synthesis of 1.
