1235982-77-0Relevant academic research and scientific papers
Organocatalytic enantioselective olefin aminofluorination
Appayee, Chandrakumar,Brenner-Moyer, Stacey E.
supporting information; scheme or table, p. 3356 - 3359 (2010/11/03)
(Equation Presented). Chiral β-fluoroamines are increasingly prevalent in medicinal compounds, but there are few efficient methods to access them from achiral starting materials. To address this, a multicomponent organocascade reaction was developed in which chiral α-fluoro-β-amino aldehydes were generated in a single flask from achiral α,β-unsaturated aldehydes (2), using catalyst 12a. Conversions up to 85%, drs up to 98:2 and ees up to 99% of the corresponding alcohol (9) were achieved in this reaction.
Sulfonyl hydrazine as new functionality in organocatalysis: Camphorsulfonyl hydrazine catalyzed enantioselective Aza-Michael addition
Chen, Ling-Yan,He, Hao,Pei, Bao-Jian,Chan, Wing-Hong,Lee, Albert W. M.
experimental part, p. 1573 - 1577 (2009/12/22)
Sulfonyl hydrazine is a new functionality for the Lewis base organocatalysis. Nα-substituted camphorsulfonyl hydrazines (CaSH) are effective organocatalysts for the asymmetric aza-Michael addition to α,β-unsaturated aldehydes with enantioselectivity of up to 90%. Georg Thieme Verlag Stuttgart.
