1235985-05-3Relevant academic research and scientific papers
Remote C-H functionalization: Using the N-O moiety as an atom-economical tether to obtain 1,5- and the rare 1,7-C-H insertions
Wang, Jingxin,Stefane, Bogdan,Jaber, Deana,Smith, Jacqueline A.I.,Vickery, Christopher,Diop, Mouhamed,Sintim, Herman O.
supporting information; experimental part, p. 3964 - 3968 (2010/09/03)
(Chemical Equotion Present) Dr. N-O: Rhodium-catalyzed intramolecular C-H insertion with diazocompounds, which are tethered by alkoxyamines, afforded 1,5- and the rare 1,7-insertion products (see scheme; Bn = benzyl). The resulting N-O tether is unaffected under the C-H insertion reaction conditions and it can be readily cleaved or transformed into various functionalities. The reduction of the N-O moiety controls acyclic stereochemistry.
