1236046-53-9

Upstream product

• 1008-89-5 2-phenylpyridine 
• 14289-45-3 2-(naphthalen-2-yl)-2-oxoacetic acid 
• 91-57-6 2-Methylnaphthalene 
• 613-46-7 2-naphthalenecarbonitrile 
• 827-54-3 2-naphthylethylene 
• 66-99-9 β-naphthaldehyde 
• 98-80-6 phenylboronic acid 
• 109-04-6 2-bromo-pyridine 
• 1221640-33-0 N,N-dimethyl-2-(pyridin-2-yl)aniline 
• 201230-82-2 carbon monoxide 
• 627906-96-1 2-(2-naphthyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 32316-92-0 naphthalene-2-boronic acid 
• 1404120-25-7 naphthalen-2-yl(2-(pyridin-2-yl)phenyl)methanol 

Downstream Products

• 1078710-42-5 2-[2-(naphthalen-2-yl)phenyl]pyridine 

Relevant academic research and scientific papers

Silver catalyzed pyridine-directed acceptorless dehydrogenation of secondary alcohols

A silver catalyzed pyridine-directed acceptorless dehydrogenation of secondary benzyl alcohols was developed. This general procedure delivers ketones with high atom-economy and hydrogen was the sole byproduct. This dehydrogenation reaction has a good functional group tolerance and high efficiency (up to 90% yield and 10,000/1 substrates-to-catalyst ratio).

Acylation of Arenes with Aldehydes through Dual C-H Activations by Merging Photocatalysis and Palladium Catalysis

An acylation of arenes with aldehydes through dual C-H activations at room temperature is reported. The acylation was initiated by phenanthraquinone-catalyzed hydrogen atom transfer from aldehyde under visible light irradiation. The aldehyde-derived acyl

Ruthenium-Catalyzed Carbonylative Coupling of Anilines with Organoboranes by the Cleavage of Neutral Aryl C-N Bond

Herein, we report the first ruthenium-catalyzed Suzuki-type carbonylative reaction of electronically neutral anilines via C(aryl)-N bond cleavage. Without any ligand and base, diaryl ketones can be obtained in moderate to high yields by using Ru3/su

Nickel-catalyzed regioselective C-H acylation of chelating arenes: A new catalytic system for C-C bond formation: Via a radical process and its mechanistic explorations

An unprecedented acylation at the ortho C-H bond of chelating arenes via the Ni(ii)-catalyzed cross dehydrogenative coupling strategy has been developed here. This new procedure exhibits excellent regioselectivity and good functional group tolerance. This discovery could be of great importance for the C-H acylation reactions of chelating arenes without any extraneous directing group and for the application of nickel-catalyzed C-H activation. Mechanistic investigations into the reaction process are also described.

Palladium-catalyzed decarboxylative, decarbonylative and dehydrogenative C(sp2)-H acylation at room temperature

Over the past few decades, an impressive array of C-H activation methodology has been developed for organic synthesis. However, due to the inherent inertness of the C-H bonds (e.g. ～110 kcal mol-1 for the cleavage of C(aryl)-H bonds) harsh reaction conditions have been realized to overcome high energetic transition states resulting in a limited substrate scope and functional group tolerance. Therefore, the development of mild C-H functionalization protocols is in high demand to exploit the full potential of the C-H activation strategy in the synthesis of a complex molecular framework. Although, electron-rich substrates undergo electrophilic metalation under relatively mild conditions, electron-deficient substrates proceed through a rate-limiting C-H insertion under forcing conditions at high temperature. In addition, a stoichiometric amount of toxic silver salt is frequently used in palladium catalysis to facilitate the C-H activation process which is not acceptable from the environmental and industrial standpoint. We report herein, a Pd(ii)-catalyzed decarboxylative C-H acylation of 2-arylpyridines with α-ketocarboxylic acids under mild conditions. The present protocol does not require stoichiometric silver(i) salts as additives and proceeds smoothly at ambient temperature. A novel decarbonylative C-H acylation reaction has also been accomplished using aryl glyoxals as acyl surrogates. Finally, a practical C-H acylation via a dehydrogenative pathway has been demonstrated using commercially available benzaldehydes and aqueous hydroperoxides. We also disclose that acetonitrile solvent is optimal for the acylation reaction at room temperature and has a prominent role in the reaction outcome. Control experiments suggest that the acylation reaction via decarboxylative, decarbonylative and dehydrogenative proceeds through a radical pathway. Thus we disclose a practical protocol for the sp2 C-H acylation reaction.

Preparation method of 2-(2-benzoyl)phenyl pyridines compound

The invention relates to a preparation method of a 2-(2-benzoyl)phenyl pyridines compound. The preparation method comprises the following steps: adding 5 mol percent of a catalyst PdCl2, 10 mol percent of a phosphine ligand XPhos, 0.3mmol of a reactant I,

Manganese-Catalyzed Direct Nucleophilic C(sp2)-H Addition to Aldehydes and Nitriles

Herein, a manganese-catalyzed nucleophilic addition of inert C(sp2)-H bonds to aldehydes and nitriles is disclosed by virtue of a dual activation strategy. The reactions feature mild reaction conditions, excellent regio- and stereoselectivity, and a wide substrate scope, which includes both aromatic and olefinic C-H bonds, as well as a large variety of aldehydes and nitriles. Moreover, mechanistic studies shed light on possible catalytic cycles.

Palladium catalyzed direct ortho C-H acylation of 2-arylpyridines using toluene derivatives as acylation reagents

A facile ortho-acylation of 2-arylpyridines by a Pd-catalyzed oxidative C-H activation was developed, in which no prefunctionalized toluene derivatives were used as acylation reagents in a tandem reaction to form 2-pyridyldiaryl ketones with moderate yiel

Decarboxylative acylation of arenes with α-oxocarboxylic acids via palladium-catalyzed C-H activation

(Equation Presented). An efficient palladium-catalyzed decarboxylative acylation of unactivated arenes with α-oxocarboxylic acids is reported. This method provides a novel access to aryl ketones.