1236055-60-9

Basic information

• Product Name: C₆₂H₈₄O₁₁Si
• Synonyms: C₆₂H₈₄O₁₁Si
• CAS NO: 1236055-60-9
• Molecular Weight: 1033.43
• Mol File: 1236055-60-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₂H₈₄O₁₁Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₂H₈₄O₁₁Si(1236055-60-9)
• EPA Substance Registry System: C₆₂H₈₄O₁₁Si(1236055-60-9)

Safety Data

• Hazardous Substances Data: 1236055-60-9(Hazardous Substances Data)

Upstream product

• 557-91-5 1,1-Dibromoethane 
• 1236055-59-6 C₆₄H₈₈O₁₂Si 

Relevant articles and documents

Synthesis of the QRSTU domain of maitotoxin and its 85- epi - And 86- epi -diastereoisomers

A devised synthetic strategy toward the QRSTU ring system 4 of the marine-derived biotoxin maitotoxin (1) delivered, in addition to 4, its diastereoisomers 85-epi-QRSTU and 86-epi-QRSTU ring systems 5 and 6. The convergent route to these maitotoxin fragments involved coupling of UT and Q building blocks 9 (obtained from 2-deoxy-d-ribose) and 10 (obtained from d-ribose) followed by ring-closing metathesis to afford enol ether 8, whose elaboration to the targeted QRSTU ring system 4 required its conversion to hydroxy ketone 7. The latter compound (7) was transformed to the final product through a hydroxy dithioketal cyclization, followed by oxidation/methylation of the resulting O,S-mixed ketal to install the last of the five methyl groups contained within the target molecule (4). 13C NMR spectroscopic analysis of synthesized fragments 4, 5, and 6 and comparisons with maitotoxin provided strong support for the originally assigned structure of the QRSTU domain of the natural product.