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123606-23-5

123606-23-5

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123606-23-5 Usage

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 6017, 1994 DOI: 10.1016/0040-4039(94)88063-8

Check Digit Verification of cas no

The CAS Registry Mumber 123606-23-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,6,0 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 123606-23:
(8*1)+(7*2)+(6*3)+(5*6)+(4*0)+(3*6)+(2*2)+(1*3)=95
95 % 10 = 5
So 123606-23-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H10N2O3/c1-5(9(11)7(8)10)6-2-3-12-4-6/h2-5,11H,1H3,(H2,8,10)

123606-23-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[1-(furan-3-yl)ethyl]-1-hydroxyurea

1.2 Other means of identification

Product number -
Other names N-1-(Fur-3-ylethyl)-N-hydroxyurea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123606-23-5 SDS

123606-23-5Downstream Products

123606-23-5Relevant articles and documents

Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors

Stewart, Andrew O.,Bhatia, Pramila A.,Martin, Jonathan G.,Summers, James B.,Rodriques, Karen E.,Martin, Michael B.,Holms, James H.,Moore, Jimmie L.,Craig, Richard A.,Kolasa, Teodozyj,Ratajczyk, James D.,Mazdiyasni, Hormoz,Kerdesky, Francis A. J.,DeNinno, Shari L.,Maki, Robert G.,Bouska, Jennifer B.,Young, Patrick R.,Lanni, Carmine,Bell, Randy L.,Carter, George W.,Brooks, Clint D. W.

, p. 1955 - 1968 (2007/10/03)

The discovery of second generation N-hydroxyurea 5-lipoxygenase inhibitors was accomplished through the development of a broad structure- activity relationship (SAR) study. This study identified requirements for improving potency and also extending duration by limiting metabolism. Potency could be maintained by the incorporation of heterocyclic templates substituted with selected lipophilic substituents. Duration of inhibition after oral administration was optimized by identification of structural features in the proximity of the N-hydroxyurea which correlated to low in vitro glucuronidation rates. Furthermore, the rate of in vitro glucuronidation was shown to be stereoselective for certain analogs. (R)-N- [3-[5-(4-Fluorophenoxy)-2-furyl]-1-methyl-2-propynyl]-N-hydroxyurea (17c) was identified and selected for clinical development.

FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS

-

, (2008/06/13)

Substituted furan and pyrrole compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase.

Substituted furan compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase

-

, (2008/06/13)

Substituted furan and pyrrole compounds of formula (I) which are useful in inhibiting lipoxygenase enzymes, particuarly 5-lipoxygenase.

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