1236136-67-6

Basic information

• Product Name: N-(2-nitrophenyl)-4-((4-(thiophen-2-yl)benzylamino)methyl)benzamide
• Synonyms: N-(2-nitrophenyl)-4-((4-(thiophen-2-yl)benzylamino)methyl)benzamide
• CAS NO: 1236136-67-6
• Molecular Weight: 443.526
• Mol File: 1236136-67-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-nitrophenyl)-4-((4-(thiophen-2-yl)benzylamino)methyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-nitrophenyl)-4-((4-(thiophen-2-yl)benzylamino)methyl)benzamide(1236136-67-6)
• EPA Substance Registry System: N-(2-nitrophenyl)-4-((4-(thiophen-2-yl)benzylamino)methyl)benzamide(1236136-67-6)

Safety Data

• Hazardous Substances Data: 1236136-67-6(Hazardous Substances Data)

Upstream product

• 107834-03-7 4-(2-thienyl)benzaldehyde 

Downstream Products

• 1257252-34-8 C₂₆H₂₃N₃O₃S 
• 1257252-41-7 C₂₆H₂₃N₃O₅S₂ 
• 1257252-68-8 C₂₇H₂₅N₃O₄S 
• 1257252-43-9 C₂₈H₂₆N₄O₄S 

Relevant articles and documents

New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group

New 2-aminobenzamide-type histone deacetylase (HDAC) inhibitors were synthesized. They feature a sulfur-containing bicyclic arylmethyl moiety-a surface recognition domain introduced to increase in cellular uptake-and a substituted tert-amino group which affects physicochemical properties such as aqueous solubility. Compound 22 with a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group reduced the volume of human colon cancer HCT116 xenografts in nude mice to T/C 67% by oral administration at 45 mg/kg, which was comparable to the rate (T/C 62%) for a positive control, MS-275. Western blot analyses as well as cell cycle and TUNEL assays by flow cytometry suggested that the two compounds inhibited the growth of cancer cells via similar mechanisms.