1236199-02-2Relevant academic research and scientific papers
Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; Formation of highly functionalized tetrasubstituted carbon centres
Quintard, Adrien,Alexakis, Alexandre
supporting information; experimental part, p. 4085 - 4087 (2010/09/06)
Aminal-pyrrolidine catalysed addition of α-hetero-disubstituted aldehydes to vinyl sulfones is described in high enantioselectivity (ee up to 97%). The obtained adducts can easily be converted to enantioenriched synthons as for example 2,2-dialkylepoxide. Evidence for a kinetic resolution is also observed.
