1236202-77-9

Upstream product

• 60838-50-8 3-methoxy-2-propenenitrile 
• 2011-48-5 1-(4-methoxybenzyl)hydrazine hydrochloride 
• 140-69-2 4-methoxybenzylhydrazine 

Downstream Products

• 1346441-44-8 C₂₀H₁₉N₅O₂ 
• 1346441-54-0 C₂₀H₁₉N₅O₂ 
• 1346441-38-0 1-(3-(1-(4-methoxybenzyl)-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea 
• 1346441-36-8 1-(3-(1-(4-methoxybenzyl)-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea 
• 1346441-32-4 1-(3,4-dichlorophenyl)-3-(3-(1-(4-methoxybenzyl)-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)urea 
• 1346441-30-2 1-(3,5-dichlorophenyl)-3-(3-(1-(4-methoxybenzyl)-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)urea 
• 1346441-26-6 1-(4-chlorophenyl)-3-(3-(1-(4-methoxybenzyl)-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)urea 
• 1346441-24-4 1-(3-chlorophenyl)-3-(3-(1-(4-methoxybenzyl)-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)urea 
• 1346441-20-0 1-(3-(1-(4-methoxybenzyl)-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)-3-(3-morpholino-5-(trifluoromethyl)phenyl)urea 
• 1346441-14-2 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(1-(4-methoxybenzyl)-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)urea 
• 1292281-67-4 N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-aminobenzamide 
• 1292281-65-2 N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-nitrobenzamide 
• 1292282-09-7 N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-4-(3-(4-(trifluoromethyl)pyrimidin-2-yl)ureido)benzamide 
• 1292282-08-6 N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-(3-(3-methylisoxazol-5-yl)ureido)benzamide 

Relevant academic research and scientific papers

Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells

The synthesis of a novel series of N-(5-amino-1-(4-methoxybenzyl)-1H- pyrazol-4-yl amide derivatives 6a-o, 7a-s and their antiproliferative activities against A375P melanoma cell line were described. Most compounds showed competitive antiproliferative act

1,4-Dihydropyrazolo[4,3-d]imidazole phenyl derivatives: A novel type II Raf kinase inhibitors

The synthesis of a novel series of 1,4-dihydropyrazolo[4,3-d]imidazole phenyl derivatives 1a-b, 2a-v and their antiproliferative activities against A375P and WM3629 human melanoma cell line were described. Most compounds showed competitive antiproliferative activities to sorafenib, the reference standard. Among them, pyrazoloimidazole phenyl urea compounds 2a, 2d, 2g, 2i, 2t exhibited potent activities on WM3629 cell lines (IC50 = 0.56-0.86 μM). Especially, 2t was found to be a potent and selective C-Raf inhibitor, showing a possibility as melanoma therapeutics.