1236267-75-6

Basic information

• Product Name: N-(4-Fluorophenyl)-2-pyrrolidinecarboxamidehydrochloride
• Synonyms: N-(4-Fluorophenyl)-2-pyrrolidinecarboxamidehydrochloride
• CAS NO: 1236267-75-6
• Molecular Formula: C11H14ClFN2O
• Molecular Weight: 244.6930632
• Mol File: 1236267-75-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-Fluorophenyl)-2-pyrrolidinecarboxamidehydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Fluorophenyl)-2-pyrrolidinecarboxamidehydrochloride(1236267-75-6)
• EPA Substance Registry System: N-(4-Fluorophenyl)-2-pyrrolidinecarboxamidehydrochloride(1236267-75-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1236267-75-6(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 371-40-4 4-fluoroaniline 

Relevant articles and documents

Design, synthesis and biological evaluation of N1-(isoquinolin-5-yl)-N2-phenylpyrrolidine-1,2-dicarboxamide derivatives as potent TRPV1 antagonists

Reported herein is the design, synthesis, and pharmacologic evaluation of a class of TRPV1 antagonists constructed on a N1-(isoquinolin-5-yl)-N2-phenylpyrrolidine-1,2-dicarboxamide platform that evolved from a 5-aminoisoquinoline urea lead. Advancing the SAR of this series led to the eventual identification of 3b, comprising a p-Br substituted phenyl. In a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels, 3b displayed potent antagonism activated by capsaicin (IC50 = 0.084 μM) and protons (IC50 = 0.313 μM). In the preliminary analgesic and body temperature tests, 3b exhibited good efficacy in capsaicin-induced and heat-induced pain models and without hyperthermia side-effect. On the basis of its superior profiles, 3b could be considered as the lead candidate for the further development of antinociceptive drugs.