1236282-94-2

Upstream product

• 1236282-73-7 N-(4-chlorobenzyl)-2-[(4-chlorobenzyl)-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-2-(4-fluorophenyl)-acetamide 
• 766-97-2 4-n-methylphenylacetylene 

Downstream Products

• 1236283-20-7 7-(4-chlorobenzyl)-6-(4-fluorophenyl)-2-isopropyl-4-methyl-5-(4-methylbenzylidene)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid 4-chlorobenzylamide 
• 1236283-22-9 7-(4-chlorobenzyl)-6-(4-fluorophenyl)-2-isopropyl-4-methyl-5-(4-methylbenzylidene)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid 4-chlorobenzylamide 

Relevant academic research and scientific papers

Toward Pyrrolo[2,3- d ]pyrimidine scaffolds

(Figure presented) Herein, we present a new route to highly substituted pyrrolo[2,3-d]pyrimidines featuring a Ugi-Smiles/Sonogashira cascade followed by an efficient base-catalyzed intramolecular cyclization. When formaldehyde is chosen as input in the Ugi-Smiles step, aromatic fused systems are eventually obtained through the isomerization of an exo-alkylidene intermediate.