1236287-04-9
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Basic information
- Product Name: Tenofovir (Maleate)
- Synonyms: Tenofovir (Maleate)
- CAS NO:1236287-04-9
- Molecular Formula: C13H18N5O8P
- Molecular Weight: 403.284481
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1236287-04-9.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in DMSO
- CAS DataBase Reference: Tenofovir (Maleate)(CAS DataBase Reference)
- NIST Chemistry Reference: Tenofovir (Maleate)(1236287-04-9)
- EPA Substance Registry System: Tenofovir (Maleate)(1236287-04-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1236287-04-9(Hazardous Substances Data)
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1236287-04-9 Usage
Biological Activity
tenofovir maleate is an inhibitor of reverse transcriptase used for the treatment of the human immunodeficiency virus 1(hiv-1) and hepatitis b [1].tenofovir maleate is an antiviral pro-drug and the class of nucleoside reverse transcriptase inhibitor. in addition, tenofovir maleate has been reported to have a dependent relation between intracellular the drug concentrations and prevent function of hiv-1infection with ec50 values of 29 fmol/106, 40 fmol/106 , 77 fmol/106 and 411 fmol/106 cells for inoculum size 1, 5, 20 and 100 respectively. and the ec50 values of tenofovir maleate are 267 fmol/106, 348 fmol/106, 640 fmol/106 and 2866 fmol/106 cells for virus inoculums size 1, 5, 20 and 100, respectively [1].references
[1] duwal s1, schütte c, von kleist m.pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against hiv-1 infection. plos one. 2012;7(7):e40382. doi: 10.1371/journal.pone.0040382. epub 2012 jul 11.Check Digit Verification of cas no
The CAS Registry Mumber 1236287-04-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,6,2,8 and 7 respectively; the second part has 2 digits, 0 and 4 respectively.Calculate Digit Verification of CAS Registry Number 1236287-04:
(9*1)+(8*2)+(7*3)+(6*6)+(5*2)+(4*8)+(3*7)+(2*0)+(1*4)=149
149 % 10 = 9
So 1236287-04-9 is a valid CAS Registry Number.
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1236287-04-9Downstream Products
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Tenofovir (Maleate)
