1236289-19-2Relevant academic research and scientific papers
Synthesis and in vitro biological evaluation of novel pyrazole derivatives as potential antitumor agents
Christodoulou, Michael S.,Fokialakis, Nikolas,Nam, Sangkil,Jove, Richard,Skaltsounis, Alexios-Leandros,Haroutounian, Serkos A.
, p. 779 - 788 (2012/10/29)
The synthesis of twenty seven novel pyrazole derivatives bearing aryl substituted groups at positions 1 and 3 of the pyrazole structural motif and various functional groups at position 4 is presented. The critical step for their synthesis is the TCT/DMF p
Novel pyrazole derivatives: Synthesis and evaluation of anti-angiogenic activity
Christodoulou, Michael S.,Liekens, Sandra,Kasiotis, Konstantinos M.,Haroutounian, Serkos A.
experimental part, p. 4338 - 4350 (2010/09/12)
The synthesis of a series of novel trisubstituted pyrazole derivatives and their PIFA-mediated conversion to molecules bearing the fused pyrazolo[4,3-c]quinoline ring system is reported. The anti-angiogenic activity of these compounds was evaluated by using in vitro assays for endothelial cell proliferation and migration, and in the chicken chorioallantoic membrane (CAM) assay. Compounds containing the fused pyrazolo[4,3-c]quinoline motifs emerged as potent anti-angiogenic compounds, which also had the ability to inhibit the growth of human breast (MCF-7) and cervical (Hela) carcinoma cells in vitro.
