1236291-95-4

Upstream product

• 353272-15-8 6-amino-4-chloro-5-iodopyrimidine 
• 54060-30-9 3-acetylenephenylamine 

Downstream Products

• 1236291-86-3 6-amino-5-((3-aminophenyl)ethynyl)-4-(3-methoxyphenoxy)pyrimidine 
• 1236291-88-5 3-(4-(3-methoxyphenoxy)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)aniline 
• 1236291-90-9 3-(4-(phenylthio)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)aniline 
• 1236291-89-6 3-(4-phenoxy-7H-pyrrolo[2,3-d]pyrimidin-6-yl)aniline 

Relevant academic research and scientific papers

Alkynyl compound and its method and use thereof

The present invention relates to an alkynyl compound and application thereof a drug for treatment of PI3-kinase abnormal-related disorder or disease in the form of a free form or a pharmaceutically acceptable salt and preparation. The present invention al

ALKYNYL COMPOUNDS AND METHODS OF USE

The invention relates to the preparation and use of new alkynyl derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity

Efficient formation of 4,6-disubstituted pyrrolo[2,3-d]pyrimidines: A novel route to TWS119, a glycogen synthase kinase-3β inhibitor

A concise synthesis of 4,6-disubstituted pyrrolo[2,3-d]pyrimidines is described. The key step involves the formation of an ether or thioether linkage along with concurrent ring closure in one-pot to yield the desired product in only two steps from a common intermediate. The reaction is chemoselective to incorporate phenol, thiophenol, and thiol. This method enabled efficient production of TWS119, a glycogen synthase kinase-3β inhibitor.