1236357-58-6

Upstream product

• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1338326-89-8 4-amino-6-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1236357-27-9 tertiary butyl 4-{4-(4-amino-5-oxo-7,8-dihydropyrimidine[5,4-f][1,4] oxazepin-6(5H)yl)-phenyl}pyridine-1-carboxylic ester 

Downstream Products

• 1236357-26-8 6-[4-(1-acetylpiperidin-4-yl)phenyl]-4-amino-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1236357-44-0 4-amino-6-[4-(1-isobutyrylpiperidin-4-yl)phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1236357-57-5 4-amino-6-{4-[1-(ethoxyacetyl)piperidin-4-yl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1236357-52-0 4-amino-6-{4-[1-(cyclohexylcarbonyl)piperidin-4-yl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1236357-33-7 4-amino-6-{4-[1-(tetrahydro-2H-pyran-4-ylcarbonyl)piperidin-4-yl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1236357-35-9 4-amino-6-(4-{1-[(cis-4-hydroxycyclohexyl)carbonyl]piperidin-4-yl}phenyl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1236357-34-8 4-amino-6-{4-[1-(1,2,5-oxadiazol-3-ylcarbonyl)piperidin-4-yl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1236357-55-3 4-amino-6-[4-(1-benzoylpiperidin-4-yl)phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1236357-42-8 4-amino-6-{4-[1-(isoxazol-5-ylcarbonyl)piperidin-4-yl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1236357-37-1 4-amino-6-{4-[1-(isoxazol-3-ylcarbonyl)piperidin-4-yl]phenyl}-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 

Relevant academic research and scientific papers

DGAT1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

The present invention discloses a novel DGAT1 inhibitor, especially the compound of formula (I) or a pharmaceutically acceptable salt thereof, preparation and pharmaceutical composition thereof, as well as their uses in the preparation of a medicament for the prevention and treatment of Familial hyperchylomicronemia (FCS), obesity, hyperlipoproteinemia or hypertriglyceridemia.

4-AMINO-5-OXO-7, 8-DIHYDROPYRIMIDO [5,4-F] [1,4] OXAZEPIN-6 (5H) -YL) PHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The invention provides compounds of Formula (I), wherein R1, R2a, R2b, R3, m and A are as defined herein, as well as compositions thereof and methods for treating a disease, condition or disorder that is modulated by the inhibition of the diacylglycerol O-acyltransferase 1 (DGAT-1) enzyme by administering the compounds of the present invention and/or compositions thereof.