123636-65-7

Upstream product

• 141848-59-1 (S)-2-{4-[(2,4-Dichloro-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 1677-44-7 4-hydroxy-6-methylquinolin-2(1H)-one 
• 123651-25-2 6-bromomethyl-2,4-dichloro-quinoline 
• 102878-18-2 2,4-dichloro-6-methyl-quinoline 

Relevant academic research and scientific papers

Quinoline derivatives having anti-tumor activity

The invention relates to a quinoline of the formula: STR1 wherein each of R1 and R2, which may be the same or different, is hydrogen, halogeno, hydroxy, cyano, carbamoyl, nitro or amino, alkyl, alkoxy, alkylthio, alkylamino, dialkyla

Quinoline antifolate thymidylate synthase inhibitors: Variation of the C2- and C4-substituents

Modifications to the bicyclic ring system of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(2-amino-3,4-dihydro-4-oxo-6- quinazolinyl)methyl]-N-prop-2-ynylamino]benzoyl]-L-glutamic acid (1, CB3717) have led to the synthesis of a series of quinol