1236360-16-9Relevant academic research and scientific papers
Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-Halo-3-phenylcoumarins
Quezada, Elias,Delogu, Giovanna,Picciau, Carmen,Santana, Lourdes,Podda, Gianni,Borges, Fernanda,Garcia-Morales, Veronica,Vina, Dolores,Orallo, Francisco
, p. 270 - 279 (2010)
A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivatives.
Ph3P/I2-Mediated Synthesis of 3-Aryl-Substituted and 3,4-Disubstituted Coumarins
Phakhodee, Wong,Duangkamol, Chuthamat,Yamano, Dolnapa,Pattarawarapan, Mookda
, p. 825 - 830 (2017/04/06)
Ph3P/I2-Et3N-mediated one-pot two-step esterification-cyclization toward 3-aryl coumarins and 3-aryl-4-methylcoumarins is reported. The reaction of a variety of aryl acetic acids containing steric or reactive group with 2-
3-Arylcoumarins: Synthesis and potent anti-inflammatory activity
Pu, Wenchen,Lin, Yuan,Zhang, Jianshuo,Wang, Fei,Wang, Chun,Zhang, Guolin
supporting information, p. 5432 - 5434 (2015/01/08)
Chronic inflammation is the persistent and excessive immune response and can lead to a variety of diseases. Aiming to discover new compounds with anti-inflammatory activity, we report herein the synthesis and biological evaluation of 3-arylcoumarins. Thirty five 3-arylcoumarins were prepared through Perkin condensation and further acid-promoted hydrolysis if necessary. In lipopolysaccharide-activated mouse macrophage RAW264.7 cells, 6,8-dichloro-3-(2-methoxyphenyl)coumarin (16) and 6-bromo-8-methoxy-3-(3-methoxyphenyl)coumarin (25) exhibited nitric oxide production inhibitory activity with the IC50 values of 8.5 μM and 6.9 μM, respectively, providing a pharmacological potential as anti-inflammatory agents.
Monoamine oxidase (MAO) inhibitory activity: 3-phenylcoumarins versus 4-hydroxy-3-phenylcoumarins
Delogu, Giovanna L.,Serra, Silvia,Quezada, Elias,Uriarte, Eugenio,Vilar, Santiago,Tatonetti, Nicholas P.,Vi?a, Dolores
supporting information, p. 1672 - 1676 (2014/08/18)
Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders. Both isoforms, MAO-A and MAO-B, are known to play critical roles in disease progression, and as such, the identification of novel, potent a
