1236360-17-0Relevant academic research and scientific papers
Monoamine oxidase (MAO) inhibitory activity: 3-phenylcoumarins versus 4-hydroxy-3-phenylcoumarins
Delogu, Giovanna L.,Serra, Silvia,Quezada, Elias,Uriarte, Eugenio,Vilar, Santiago,Tatonetti, Nicholas P.,Vi?a, Dolores
, p. 1672 - 1676 (2014)
Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders. Both isoforms, MAO-A and MAO-B, are known to play critical roles in disease progression, and as such, the identification of novel, potent a
Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-Halo-3-phenylcoumarins
Quezada, Elias,Delogu, Giovanna,Picciau, Carmen,Santana, Lourdes,Podda, Gianni,Borges, Fernanda,Garcia-Morales, Veronica,Vina, Dolores,Orallo, Francisco
experimental part, p. 270 - 279 (2010/05/18)
A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivatives.
